Enter a variant below to see its SpliceAI and Pangolin scores.

This web interface and the underlying SpliceAI server are developed and maintained by the TGG at the Broad Institute.
The SpliceAI server optionally uses pre-computed scores provided by Illumina for SNVs and small InDels, but runs the SpliceAI model directly for scores not available in the pre-computed files - such as for larger InDels, non-default "Max distance" values, etc.

NOTE: The server supports not more than several queries per-minute per-user. If you need to batch-process many variants, please use the source code to set up your own local instance of the API server or just run the underlying SpliceAI model directly.

For more information about the SpliceAI model, see Jaganathan et al, Cell 2019 and github.com/Illumina/SpliceAI, and this recorded talk by Kishore Jaganathan.

Since February 2023, Pangolin scores from [Zeng & Li 2022] are also shown below the SpliceAI results.